Dr. rer. nat. Ulrich Weininger
Interests
- Dynamics of catalytic residues
- Hierachy of the processes in the active sites of enzymes
- Protonation kinetics in tyrosines and histidines
- Transient tautomerisation of histidines - influence on the hydrogen bond network
- Ring-flips as probes of protein breathing
- Ring-flips as probes of aromatic interaction strength
- pKa values in proteins
- Dynamics of methyl- and carboxylgroups in proteins
- Protein folding and misfolding
- Protein folding intermediates
- Structure determination of proteins in solution
Methods
- selective 13C labeling of proteins
- relaxation optimized NMR spectroscopy
- protein dynamics by NMR-spectroscopy:
- R2 relaxation dispersion (up to 2 000 s-1)
- R1ρ relaxation dispersion (up to 30 000 s-1)
- R2 vs pH experiments (up to 2 000 000 s-1)
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