Martin-Luther-Universität Halle-Wittenberg

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Publikationen Ulrich Weininger

40. Weininger U, Modig K, Geitner A, Schmidpeter P, Koch J, Akke M(2016) Biochemistry: 334-343.

'Dynamics of Aromatic Side Chains in the Active Site of FKBP12.'

39. Quistgaard EM, Weininger U, Ural-Blimke Y, Modig K, Nordlund P, Akke M, Löw C (2016) BMC Biol. 14(1): 82.

'Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.'

38. Herling TW, O'Connell DJ, Bauer MC, Persson J, Weininger U, Knowles TP, Linse S. (2016) Biophys J 110(9): 1957-66.

'A Microfluidic Platform for Real-Time Detection and Quantification of Protein-Ligand Interactions.'

37. Zimmermann S, Pfennig S, Neumann P, Yonus H, Weininger U, Kovermann M, Balbach J, Stubbs MT. (2015) FEBS Lett 589(18): 2283-9.

'High-resolution structures of the D-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-forms.'

36. Kölbel K, Weininger U, Ihling C, Mrestani-Klaus C, Ulbrich-Hofmann R. (2015) Biophys Chem 206: 12-21.

'Native state dynamics affects the folding transition of porcine pancreatic phospholipase A2.'

35. Cukalevski R, Yang X, Meisl G, Weininger U, Bernfur K, Frohm B, Knowles TP, Linse S. (2015) Chem Sci 6(7): 4215-33.

'The Aß40 and Aß42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.'

34. Wallerstein J, Weininger U, Khan MA, Linse S, Akke M. 2015) J Am Chem Soc 137(8): 3093-101.

'Site-Specific Protonation Kinetics of Acidic Side Chains in Proteins Determined by pH-Dependent Carboxyl (13)C NMR Relaxation.'

33. Rämisch S, Weininger U, Martinsson J, Akke M, André I. (2014) Proc Natl Acad Sci USA 111(50): 17875-80.

'Computational design of a leucine-rich repeat protein with a predefined geometry.'

32. Weininger U, Modig K, Akke M. (2014) Biochemistry 53(28): 4519-25.

'Ring flips revisited: (13)C relaxation dispersion measurements of aromatic side chain dynamics and activation barriers in basic pancreatic trypsin inhibitor.'

31. Weininger U, Brath U, Modig K, Teilum K, Akke M. (2014) J Biomol NMR 59(1): 23-9.

'Off-resonance rotating-frame relaxation dispersion experiment for 13C in aromatic side chains using L-optimized TROSY-selection.'

30. Weininger U, Blissing AT, Hennig J, Ahlner A, Liu Z, Vogel HJ, Akke M, Lundström P. (2013) J Biomol NMR 57(1): 47-55.

'Protein conformational exchange measured by 1H R1ρ relaxation dispersion of methyl groups.'

29. Weininger U, Respondek M, Löw C, Akke M. (2013) J Phys Chem B 117(31): 9241-7.

'Slow aromatic ring flips detected despite near-degenerate NMR frequencies of the exchanging nuclei.'

28. Hoffmann-Thoms S, Weininger U, Eckert B, Jakob RP, Koch JR, Balbach J, Schmid FX. (2013) J Biol Chem 288(18): 12979-91.

'Initiation of phage infection by partial unfolding and prolyl isomerization.'

27. Weininger U, Liu Z, McIntyre DD, Vogel HJ, Akke M. (2012) J Am Chem Soc 134(45): 18562-5.

'Specific 12CßD(2)12CγD(2)S13CεHD(2) isotopomer labeling of methionine to characterize protein dynamics by 1H and 13C NMR relaxation dispersion.'

26. Weininger U, Respondek M, Akke M. (2012) J Biomol NMR 54(1): 9-14.

'Conformational exchange of aromatic side chains characterized by L-optimized TROSY-selected ¹³C CPMG relaxation dispersion.'

25. Weininger U, Diehl C, Akke M. (2012) J Biomol NMR 53(3): 181-90.

'¹³C relaxation experiments for aromatic side chains employing longitudinal- and transverse-relaxation optimized NMR spectroscopy.'

24. Jakob RP, Geitner AJ, Weininger U, Balbach J, Dobbek H, Schmid FX. (2012) Mol Microbiol 84(6): 1124-38.

'Structural and energetic basis of infection by the filamentous bacteriophage IKe.'

23. Saraboji K, Håkansson M, Genheden S, Diehl C, Qvist J, Weininger U, Nilsson UJ, Leffler H, Ryde U, Akke M, Logan DT. (2012) Biochemistry 51(1): 296-306.

'The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics.'

22. Casares-Atienza S, Weininger U, Cámara-Artigas A, Balbach J, Garcia-Mira MM. (2011) Biophys Chem 159(2-3): 267-74.

'Three-state thermal unfolding of onconase.'

21. Haupt C, Weininger U, Kovermann M, Balbach J. (2011) Biochemistry 50(34): 7321-9.

'Local and coupled thermodynamic stability of the two-domain and bifunctional enzyme SlyD from Escherichia coli.'

20. Haupt C, Patzschke R, Weininger U, Gröger S, Kovermann M, Balbach J. (2011) J Am Chem Soc 133(29): 11154-62.

'Transient enzyme-substrate recognition monitored by real-time NMR.'

19. Lorenz SH, Jakob RP, Weininger U, Balbach J, Dobbek H, Schmid FX. (2011) J Mol Biol 405(4): 989-1003.

'The filamentous phages fd and IF1 use different mechanisms to infect Escherichia coli.'

18. Lilie H, Bär D, Kettner K, Weininger U, Balbach J, Naumann M, Müller EC, Otto A, Gast K, Golbik R, Kriegel T. (2011) Protein Eng Des Sel 24(1-2): 79-87.

'Yeast hexokinase isoenzyme ScHxk2: stability of a two-domain protein with discontinuous domains.'

17. Jakob RP, Zierer BK, Weininger U, Hofmann SD, Lorenz SH, Balbach J, Dobbek H, Schmid FX. (2010) J Mol Biol 399(2): 331-46.

'Elimination of a cis-proline-containing loop and turn optimization stabilizes a protein and accelerates its folding.'

16. Schulenburg C, Weininger U, Neumann P, Meiselbach H, Stubbs MT, Sticht H, Balbach J, Ulbrich-Hofmann R, Arnold U. (2010) Chembiochem 11(7): 978-86.

'Impact of the C-terminal disulfide bond on the folding and stability of onconase.'

15. Löw C, Neumann P, Tidow H, Weininger U, Haupt C, Friedrich-Epler B, Scholz C, Stubbs MT, Balbach J. (2010) J Mol Biol 398(3): 375-90.

'Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus.'

14. Weininger U, Jakob RP, Kovermann M, Balbach J, Schmid FX. (2010) Protein Sci 19(1): 6-18.

'The prolyl isomerase domain of PpiD from Escherichia coli shows a parvulin fold but is devoid of catalytic activity.'

13. Weininger U, Zeeb M, Neumann P, Löw C, Stubbs MT, Lipps G, Balbach J. (2009) Biochemistry 48(42): 10030-7.

'Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus.'

12. Schulenburg C, Löw C, Weininger U, Mrestani-Klaus C, Hofmann H, Balbach J, Ulbrich-Hofmann R, Arnold U. (2009) Biochemistry 48(35): 8449-57.

'The folding of onconase is directed by a conserves intermediate.'

11. Weininger U, Jakob RP, Eckert R, Schweimer K, Schmid FX, Balbach J. (2009) Proc Natl Acad Sci USA 106(30): 12335-40.

'A remote prolyl isomerization controls domain assembly via a hydrogen bonding network.'

10. Weininger U, Haupt C, Schweimer K, Graubner W, Kovermann M, Brüser T, Scholz C, Schaarschmidt P, Zoldak G, Schmid FX, Balbach J. (2009) J Mol Biol 387(2): 295-305.

'NMR solution structure of SlyD from Escherichia coli: spatial separation of prolyl isomerase and chaperone function.'

9. Löw C, Homeyer N, Weininger U, Sticht H, Balbach J. (2009) ACS Chem Biol 4(1): 53-63.

'Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state.'

8. Hofmann H, Weininger U, Löw C, Golbik RP, Balbach J, Ulbrich-Hofmann R. (2009) J Am Chem Soc 131(1): 140-6.

'Fast amide proton exchange reveals close relation between native-state dynamics and unfolding kinetics.'

7. Hoffmann A, Funkner A, Neumann P, Juhnke S, Walther M, Schierhorn A, Weininger U, Balbach J, Reuter G, Stubbs MT. (2008) J Biol Chem 283(47): 32598-609.

'Biophysical characterization of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms.'

6. Löw C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J. (2008) Biophys J 95(9): 4315-23.

'Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers.'

5. Löw C, Weininger U, Neumann P, Klepsch M, Lilie H, Stubbs MT, Balbach J. (2008) Proc Natl Acad Sci USA 105(10): 3779-84.

'Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein.'

4. Bosse-Doenecke E, Weininger U, Gopalswamy M, Balbach J, Knudsen SM, Rudolph R. (2008) Protein Expr Purif 58(1): 114-21.

'High yield production of recombinant native and modified peptides exemplified by ligands for G-protein coupled receptors.'

3. Löw C, Weininger U, Zeeb M, Zhang W, Laue ED, Schmid FX, Balbach J. (2007) J Mol Biol 373(1): 219-31.

'Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d).'

2. Zeeb M, Max KE, Weininger U, Löw C, Sticht H, Balbach J. (2006) Nucleic Acids Res 34(16): 4561-71.

'Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution.'

1. Kliemannel M, Weininger U, Balbach J, Schwarz E, Rudolph R. (2006) Biochemistry 45(11): 3517-24.

'Examination of the slow unfolding of pro-nerve growth factor argues against a loop threading mechanism for nerve growth factor.'


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