Publikationen
Journalpublikationen:
'The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation.'
123. Balbach J., Stubbs M.T. (2023) Science, 381(6654): 126.
'Coupling proteins, with deadly consequences.'
122. Voigt B., Ott M., Balbach J. (2023) Macromol Biosci., 23(4): e2200525.
'A Competition of Secondary and Primary Nucleation Controls Amyloid Fibril Formation of the Parathyroid Hormone.'
'Early Stage UV-B Induced Molecular Modifications of Human Eye Lens γD-Crystallin.'
120. Sachan S., Moya C.G., Voigt B., Köhn M., Balbach J. (2023) FEBS Lett., 597(7): 995.
'The pro-sequence of parathyroid hormone prevents premature amyloid fibril formation.'
'Heparin promotes rapid fibrillation of the basic parathyroid hormone at physiological pH.'
118. Dreydoppel M., Balbach J., Weininger U. (2022) J Biomol NMR, 76(1-2): 3.
'Monitoring protein unfolding transitions by NMR-spectroscopy.'
'Macromolecular Crowding Induces a Binding Competent Transient Structure in Intrinsically Disordered Gab1.'
116. Kumar A., Balbach J.
(2021) Biomolecules, 11(6): 840. 'Folding and Stability of Ankyrin Repeats Control Biological Protein Function.'
115. Kumar A., Balbach J.
(2022) Curr Mol Pharmacol 15(2): 292. 'Inactivation of parathyroid hormone: perspectives of drug discovery to combating hyperparathyroidism.'
114. Auerswald A., Gruber T., Balbach J., Meister A.
(2020) Langmuir, 36(30): 8695-8704. 'Lipid-Dependent Interaction of Human N-BAR Domain Proteins with Sarcolemma Mono- and Bilayers.' 'Insights into the secondary structures of lactam N-substituted stapled peptides.' 'Synthesis and Aggregation of Polymer‐Amyloid β Conjugates.'
111. Kumar A., Kuhn L.T., Balbach J. (2019) Int J Mol Sci, 20(2): 378. 'In-Cell NMR: Analysis of Protein–Small Molecule Interactions, Metabolic Processes, and Protein Phosphorylation.'
110. Wägele J., De Sio S., Voigt B., Balbach J., Ott M. (2019) J Biophys J, 116(2): 227-238. 'How Fluorescent Tags Modify Oligomer Size Distributions of the Alzheimer Peptide.' 'Hyperbolic Pressure-Temperature Phase Diagram of the Zinc-Finger Protein apoKti11 Detected by NMR Spectroscopy.' 'A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge.' 'Equilibrium and Kinetic Unfolding of GB1: Stabilization of the Native State by Pressure.' 'Probing polymer chain conformation and fibril formation of peptide conjugates.' 'Quantitative NMR study of heat-induced aggregation of eye-lens crystallin proteins under crowding conditions'
104. Kumar A., Kuhn L.T., Balbach J. (2018) FEBS J., 285: 3013-3025. 'A Cu2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53.' 'Phosphorylation-induced unfolding regulates p19INK4d during the human cell cycle.' 'Structure-Based Insights into the Dynamics and Function of Two-Domain SlpA from Escherichia coli.'
101. Kumar A., Balbach J. (2017) Sci rep., 7: 42141. 'Targeting the molecular chaperone SlyD to inhibit bacterial growth with a small molecule.' 'Transient binding accounts for apparent violation of the generalized Stokes–Einstein relation in crowded protein solutions.' 'Coupling and Decoupling of Rotational and Translational Diffusion of Proteins under Crowding Conditions.' 'A Detailed Analysis of the Morphology of Fibrils of Selectively Mutated Amyloid β (1–40).' 'Inhibition of Aβ(1–40) fibril formation by cyclophilins.' 'Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides.'
95. Kumar, A., Balbach, J. (2015) Biochem. Biophys. Acta, 1850(10): 1965-1972. 'Real-time protein NMR spectroscopy and investigation of assisted protein folding.'
94. Kumar, A., Baumann, M., Balbach, J. (2016) Sci rep., 6: 22533. 'Small Molecule Inhibited Parathyroid Hormone Mediated cAMP Response by N–Terminal Peptide Binding.' 'The "long tail" of the protein tumbling correlation function: observation by 1H NMR relaxometry in a wide frequency and concentration range.' 'Molecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation.'
91. Gruber, T., Balbach, J. (2015) PLOS ONE, 10(9): e0136922. 'Protein folding mechanism of the dimeric AmphiphysinII/Bin1 N-BAR domain.' 'Supramolecular organization of the human N-BAR domain in shaping the sarcolemma membrane.' 'High-resolution structures of the d-alanyl carrier protein (Dcp) DltC from Bacillus subtilis reveal equivalent conformations of apo- and holo-forms.' 'Novel sulfated phosphoglycolipids from Natronomonas moolapensis.' 'Solution structure of the PsIAA4 dimerization domain reveals interaction modes for transcription factors in early auxin response.' 'NMR-Detected Brownian Dynamics of αB-Crystallin over a Wide Range of Concentrations.' 'Structural characterization of amyloid fibrils from the human parathyroid hormone.' 'Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2.' 'Biophysical and structural characterization of a folded core domain within the proregion of growth and differentiation factor-5.' 'N-Terminal Phosphorylation of Parathyroid Hormone (PTH) Abolishes Its Receptor Activity.' 'Initiation of RNA Synthesis by the Hepatitis C Virus RNA-Dependent RNA Polymerase Is Affected by the Structure of the RNA Template.' 'Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.'
79. Kovermann, M., Schmid, F.X., Balbach, J. (2013) Biol. Chem., 394, 965-975. 'Molecular function of the prolyl cis/trans isomerase and metallochaperone SlyD.'
78. Hacke, M., Gruber, T., Schulenburg, C., Balbach, J., Arnold, U. (2013) FEBS J., 280, 4454-4462. 'Consequences of proline-to-alanine substitutions for the stability and refolding of onconase.'
77. Krug, U., Patzschke, R., Zebisch, M., Balbach, J., Sträter, N. (2013) FEBS Lett., 587, 460-466. 'Contribution of the two domains of E. coli 5′-nucleotidase to substrate specificity and catalysis.'
76. Kovermann, M., Balbach, J. (2013) Biophys. Chem., 171, 16-23. 'Dynamic control of the prolyl isomerase function of the dual-domain SlyD protein.' 'Initiation of Phage Infection by Partial Unfolding and Prolyl Isomerization.' 'Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.' 'Structural and energetic basis of infection by the filamentous bacteriophage IKe.' 'Nickel Binding and [NiFe]-Hydrogenase Maturation by the Metallochaperone SlyD with a Single Metal-Binding Site in Escherichia coli.' 'New Binding Mode to TNF-Alpha Revealed by Ubiquitin-Based Artificial Binding Protein .' 'Escherichia coli Peptide Binding Protein OppA Has a Preference for Positively Charged Peptides.'
69. Sachs, R., Max, K.E.A., Heinemann, U., Balbach, J. (2011) RNA, 18, 65-76. 'RNA single strands bind to a conserved surface of the major cold shock protein in crystals and solution.' 'Three-state thermal unfolding of onconase.'
67. Haupt, C., Weininger, U., Kovermann, M., Balbach, J. (2011) Biochemistry, 50, 7321-7329. 'Local and Coupled Thermodynamic Stability of the Two-Domain and Bifunctional Enzyme SlyD from Escherichia coli.' 'Conformational Plasticity and Dynamics in the Generic Protein Folding Catalyst SlyD Unraveled by Single-Molecule FRET.' 'Transient Enzyme–Substrate Recognition Monitored by Real-Time NMR.' 'Phosphate and HEPES buffers potently affect the fibrillation and oligomerization mechanism of Alzheimer’s Aβ peptide.' 'NMR relaxation unravels interdomain crosstalk of the two domain prolyl isomerase and chaperone SlyD.' 'The presence of membranes or micelles induces structural changes of the myristoylated guanylate-cyclase activating protein-2.' 'Binding specificity of the ectodomain of the parathyroid hormone receptor.' 'The Filamentous Phages fd and IF1 Use Different Mechanisms to Infect Escherichia coli.' 'Yeast hexokinase isoenzyme ScHxk2: stability of a two-domain protein with discontinuous domains.' 'Aggregation and Chain Dynamics in Supramolecular Polymers by Dynamic Rheology: Cluster Formation and Self-Aggregation.' 'DHPC Strongly Affects the Structure and Oligomerization Propensity of Alzheimer's Aβ(1–40) Peptide.' 'Elimination of a cis-Proline-Containing Loop and Turn Optimization Stabilizes a Protein and Accelerates Its Folding.' 'Crystal Structure Determination and Functional Characterization of the Metallochaperone SlyD from Thermus thermophilus.' 'Impact of the C-terminal Disulfide Bond on the Folding and Stability of Onconase.' 'The prolyl isomerase domain of PpiD from Escherichia coli shows a parvulin fold but is devoid of catalytic activity.' 'A remote prolyl isomerization controls domain assembly via a hydrogen bonding network.' 'Structure-Based Stability Analysis of an Extremely Stable Dimeric DNA Binding Protein from Sulfolobus islandicus.' 'The Folding Pathway of Onconase Is Directed by a Conserved Intermediate.' 'Coordination chemistry approach to the long-standing challenge of stereocontrolled chemical glycosylation.' 'NMR Solution Structure of SlyD from Escherichia coli: Spatial Separation of Prolyl Isomerase and Chaperone Function.'
47. Löw C., Homeyer N., Weininger U., Sticht H., Balbach J. (2009) ACS Chem. Bio, 4, 53-63. 'Conformational Switch upon Phosphorylation: Human CDK Inhibitor p19(INK4d) between the Native and Partially Folded State.' 'Fast Amide Proton Exchange Reveals Close Relation between Native-State Dynamics and Unfolding Kinetics.' 'Biophysical Characterization of Refolded Drosophila Spätzle, a Cystine Knot Protein, Reveals Distinct Properties of Three Isoforms.' 'Structure and Dynamics of Helix-0 of the N-BAR Domain in Lipid Micelles and Bilayers.' 'Monitoring fibril formation of the N-terminal domain of PABPN1 carrying an alanine repeat by tryptophan fluorescence and real-time NMR.' 'Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein.' 'High yield production of recombinant native and modified peptides exemplified by ligands for G-protein coupled receptors.' 'Hofmeister Salts and Potential Therapeutic Compounds Accelerate in Vitro Fibril Formation of the N-Terminal Domain of PABPN1 Containing a Disease-Causing Alanine Extension.' 'Folding Mechanism of an Ankyrin Repeat Protein: Scaffold and Active Site Formation of Human CDK Inhibitor p19(INK4d).'
38. Max, K.E., Zeeb, M. Bienert, R., Balbach, J., Heinemann, U. (2007) FEBS J., 274, 1265-1279. 'Common mode of DNA binding to cold shock domains.' 'Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution.'
36. Max, K.E., Zeeb, M., Bienert, R., Balbach, J., Heinemann, U. (2006) J. Mol. Biol., 360, 702-714. 'T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB.' 'Examination of the Slow Unfolding of Pro-Nerve Growth Factor Argues against a Loop Threading Mechanism for Nerve Growth Factor.' 'SlyD Proteins from Different Species Exhibit High Prolyl Isomerase and Chaperone Activities.'
33. Szyperski, T., Mills, J.L., Perl, D., Balbach, J. (2005) Eur. Biophys. J., 35, 363-366. 'Combined NMR-observation of cold denaturation in supercooled water and heat denaturation enables accurate measurement of ΔCp of protein unfolding.'
32. Zeeb, M., Balbach, J. (2005) J. Am. Chem. Soc., 127, 13207-13212. 'NMR Spectroscopic Characterization of Millisecond Protein Folding by Transverse Relaxation Dispersion Measurements.' 'The influence of cold shock proteins on transcription and translation studied in cell-free model systems.'
30. Eckert, B., Martin, A., Balbach, L., Schmid, F.X. (2005) Nat. Struct. Mol. Biol., 12, 619-623. 'Prolyl isomerization as a molecular timer in phage infection.' 'Functional Solubilization of Aggregation-prone HIV Envelope Proteins by Covalent Fusion with Chaperone Modules.'
28. Zeeb, M., Balbach, J. (2005) Prot. Pept. Lett., 12, 139-146. 'Millisecond Protein Folding Studied by NMR Spectroscopy.'
27. Zeeb, M., Balbach, J. (2004) Methods, 34, 65-74. 'Protein folding studied by real-time NMR spectroscopy.' 'The mature part of proNGF induces the structure of its pro-peptide.' 'Single-stranded DNA bound to bacterial cold-shock proteins: preliminary crystallographic and Raman analysis.'
24. Zeeb, M., Lipps, G., Lilie, H., Balbach, J. (2004) J. Mol. Biol., 336, 227-240. 'Folding and Association of an Extremely Stable Dimeric Protein from Sulfolobus islandicus.'
23. Zeeb, M., Jacob, M.H., Schindler, T., M., Balbach, J. (2003) J. Biomol. NMR, 27, 221-234. '15N relaxation study of the cold shock protein CspB at various solvent viscosities.'
22. Zeeb, M., Balbach, J. (2003) Protein Science, 12, 112-123. 'Single-stranded DNA binding of the cold-shock protein CspB from Bacillus subtilis: NMR mapping and mutational characterization.' 'Protein folding and stability of human CDK inhibitor p19(INK4d).'
20. Steegborn, C., Schneider-Hassloff, H., Zeeb, M., Balbach, J. (2000) Biochemistry, 39, 7910-7919. 'Cooperativity of a Protein Folding Reaction Probed at Multiple Chain Positions by Real-Time 2D NMR Spectroscopy.'
19. Balbach, J. (2000) J. Am. Chem. Soc., 122, 5887-5888. 'Compaction during Protein Folding Studied by Real-Time NMR Diffusion Experiments.' 'Rapid collapse and slow structural reorganisation during the refolding of bovine α-lactalbumin.'
17. Balbach, J., Steegborn, C., Schindler, T., Schmid, F.X. (1999) J. Mol. Biol., 285, 829-842. 'A protein folding intermediate of ribonuclease T1 characterized at high resolution by 1D and 2D real-time NMR spectroscopy.'
16. van Nuland, N.A.J, Balbach, J., Forge, V., Dobson, C.M. (1998) Acc. Chem. Res., 31, 773-780. 'Real-Time NMR Studies of Protein Folding.' 'Structure and dynamic properties of the single disulfide-deficient α-amylase inhibitor [C45A/C73A]tendamistat: An NMR study.' 'Detection of residue contacts in a protein folding intermediate.' 'Diffusion control in an elementary protein folding reaction.' 'New NMR approaches for studying protein folding.' 'Protein Folding Monitored at Individual Residues During a Two-Dimensional NMR Experiment.' 'Following protein folding in real time using NMR spectroscopy.'
9. Balbach, J., Kessler, H. (1994) J. Magn. Reson., Series B, 105, 83-87. '13C-Edited Double-Quantum Spectroscopy of Peptides and Proteins' 'Mannose Transporter of Escherichia coli. Backbone Assignments and Secondary Structure of the IIA Domain of the IIABMan Subunit.' 'Predicted topology of the N-terminal domain of the hydrophilic subunit of the mannose transporter of Escherichia coli.'
6. Seip, S., Balbach, J., Kessler, H. (1994) J. Magn. Reson., Series B , 104, 172-179. 'Determination of backbone conformation of isotopically enriched proteins based on coupling constants.'
5. Seip, S., Balbach, J., Kessler, H. (1993) J. Biomol. NMR , 3, 233-237. 'A simple way for sequential assignment in isotopically enriched proteins using a H(N)CACO correlation.' 'New heteronuclear NMR Techniques for the determination of structures and Dynamics of peptides and proteins - consequences for drug design'
3. Seip, S., Balbach, J., Kessler, H. (1992) Angew. Chem. Int. Ed., 31, 1609-1611. 'Determination of the HN–Hα Coupling Constant in Large Isotopically Enriched Proteins.'
2. Seip, S., Balbach, J., Kessler, H. (1992) J. Magn. Reson. , 100, 406-410. 'An improved technique for correlating backbone amide protons with 15N and Ha protons (HN(CA)H) in isotopically enriched proteins.'
1. Mronga, S., Balbach, J. (1992) J. Magn. Reson., 98, 421-427. 'Multiplet structure in real cosine fourier-transformed zero-quantum spectra without axial peaks.' Übersichtsartikel:
12. Balbach J., Stubbs M.T.
(2023) Science, 381(6654): 126. 'Coupling proteins, with deadly consequences.' 'Lighting up Nobel Prize-winning studies with protein intrinsic disorder.'
10. Dreydoppel M., Balbach J., Weininger U.
(2022) J Biomol NMR, 76(1-2): 3. 'Monitoring protein unfolding transitions by NMR-spectroscopy.'
9. Kumar A., Balbach J.
(2022) Curr Mol Pharmacol 15(2): 292. 'Inactivation of parathyroid hormone: perspectives of drug discovery to combating hyperparathyroidism.'
8. Kumar A., Balbach J.
(2021) Biomolecules, 11(6): 840. 'Folding and Stability of Ankyrin Repeats Control Biological Protein Function.'
7. Kumar A., Kuhn L.T., Balbach J. (2019) Int J Mol Sci, 20(2): 378. 'In-Cell NMR: Analysis of Protein–Small Molecule Interactions, Metabolic Processes, and Protein Phosphorylation.' 65. Kumar, A., Balbach, J. (2015) Biochem. Biophys. Acta, 1850(10): 1965-1972. 'Real-time protein NMR spectroscopy and investigation of assisted protein folding.'
5. Kovermann, M., Schmid, F.X., Balbach, J. (2013) Biol. Chem., 394, 965-975. 'Molecular function of the prolyl cis/trans isomerase and metallochaperone SlyD.'
4. Zeeb, M., Balbach, J. (2005) Prot. Pept. Lett., 12, 139-146. 'Millisecond Protein Folding Studied by NMR Spectroscopy.'
3. Zeeb, M., Balbach, J. (2004) Methods, 34, 65-74. 'Protein folding studied by real-time NMR spectroscopy.'
2. van Nuland, N.A.J, Balbach, J., Forge, V., Dobson, C.M. (1998) Acc. Chem. Res., 31, 773-780. 'Real-Time NMR Studies of Protein Folding.' 'New NMR approaches for studying protein folding.' Buchbeiträge
6. Weininger U. (2019) Methods Enzymol., 614: 67-86. 'Optimal Isotope Labeling of Aromatic Amino Acid Side Chains for NMR Studies of Protein Dynamics.' 'Metallochaperone SlyD.'
4. Weininger, U., Balbach, J. (2006) in: ‘Protein Structures: Methods in Protein Structure and Stability Analysis’ (V.N. Uversky, ed.), Nova Science Publishers, New York. 'Analyzing protein folding by NMR.' 'Kinetic Protein Folding Studies using NMR Spectroscopy.'
2. Zeeb, M., Balbach, J. (2001) Nova Acta Leopoldina, Supp. 16, 57-58. 'DNA binding and micro-viscosity effects on the folding of CspB .'
1. Balbach, J., Schmid, F.X. (2000) in 'Mechanisms of protein folding' (R.H. Pain, ed.), Oxford University Press. 'Proline isomerization and its catalysis in protein folding.'