C. J. Waschinski, S. Barnert, A. Theobald, R. Schubert, F. Kleinschmidt, A.
Hoffmann, K. Saalwächter, J. C. Tiller.
Insights in the Antibacterial Action of Poly(methyloxazoline)s with a Biocidal
End Group and Varying Satellite Groups.
Biomacromolecules 9, 1764–1771 (2008). DOI
The antimicrobial activity of poly(2-methyl-1,3-oxazoline)s (PMOX) with the
antimicrobial N,N-dimethyldodecylammonium (DDA) end group is greatly dependent
on the nature of the group at the distal end of the polymer, the satellite
group. Three comparable PMOX with a DDA end group and different satellite groups
(methyl, decyl, hexadecyl) were investigated with respect to the reasons for the
huge differences in their biocidal behavior. Static light scattering (SLS) and
pulsed field gradient diffusion NMR measurements revealed that the samples show
comparable aggregation conduct, thus, not being responsible for the varying
biological activity. Experiments using different liposomal systems as models for
bacterial cell membranes have been performed. It was found that differential
interactions between the respective polymers and the phospholipid membranes
constitute the reason for the varying effectiveness observed in antimicrobial