K. Saalwächter, A. Ramamoorthy.
Sensitivity Enhancement by Inverse Detection in Solids.
In: NMR of Biological Solids. Editor: A. Ramamoorthy.
Taylor and Francis, Boca Raton 2006.
The most disappointing aspect of solid-state NMR spectroscopy is the requirement
of a large amount of sample and/or a long acquisition time. Some of the most
interesting biomolecules, such as membrane proteins and RNA, are not abundantly
available and also do not withstand long high power solid-state NMR experiments.
Therefore, there is a considerable interest in developing methods to increase
the sensitivity of this powerful tool. To accomplish this goal, a number of
proton-detection techniques have recently been reported. In this chapter, we
address the need for higher sensitivity experiments, discuss the difficulties in
designing such techniques, and explain the merits of different types of