- N. Sonnenberger, N. Anders, Y. Golitsyn, M. Steinhart, D. Enke, K. Saalwächter, M. Beiner.
Pharmaceutical nanocrystals confined in porous
host systems – interfacial effects and amorphous
Chem. Commun. 52, 4466-4469 (2016).
DSC and NMR results prove the existence of an amorphous acetaminophen nanolayer between acetaminophen nanocrystals (form I and form III) and pore walls in controlled porous glasses. This nanolayer controls the surface energy. This finding is highly relevant for approaches towards crystal engineering in nanopores and indicates similarities to the situation during the early stages of crystallization in polymorphic bulk samples.